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KMID : 0614020080230010041
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Journal of Pharmaceutical Sciences (C.N.U.)
2008 Volume.23 No. 1 p.41 ~ p.46
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Imhibitory Effect of Black Genseng Manufactured by New Method on Atopic Dermatitis
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Kim Eui-Keom
Lee Jee-Hyun
Shen Gui-nan
Cho Soo-Hyun
Kim Long-Guo
Lee Ji-Sook
Park Yong-Jin
Yun Chi-Young
Song Gyu-Yong
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Abstract
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The purpose of this study was to investigate the effects of crude saponin fraction of black ginseng(SFBG) on atopic dermatitis in vitro. The house dust mite(Dermatophagoides pteronissinus, DP) plays a key role in the pathogenesis of allergic diseases, including atopic dermatitis and asthma. Monocyte chemo-attractant protein 1(MCP-1/CCL2)/interleukin-6(IL-6)/IL-8(CXCL8) plays a pivotal role in mediating the infiltration of various cells into the skin of atopic dermatitis. We found that SFBG potently suppressed the elevated production of MCP-1, IL-6 and IL-8 induced by D. pteronissinus extract(DpE) treatment in the human monocytic cell line, THP-1 cells. Also, SFBG potently suppressed the elevated production of IL-6 and IL-8 induced by DpE treatment in the human eosinophilic cell line, EoL-1 cells. These results suggest that SFBG have an anti-atopic property, and that in future further development of main effective constituents in SFBG can provide a novel therapeutic agent for atopic dermatitis.
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KEYWORD
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black ginseng, atopic der, atitis, cytokine
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